After decades of research - a drug-free, all-natural, effective treatment.

Introducing the miracle of bioavailable, topical polyphenols - a breakthrough natural therapy now available through Stress-Negated Lotion.

Polyphenols, compounds found in plant-based foods, have been part of the human diet for centuries. Although the term "polyphenol" has been used only since 1894 (ScienceDirect), their medicinal and nutritional use dates back much further. Their health benefits - especially antioxidant and anti-inflammatory effects - have been increasingly studied since the 1990s.

Now, through advanced transdermal delivery technology, we make polyphenols bioavailable through the skin, ensuring their full therapeutic potential is preserved and absorbed directly into the bloodstream.

WHY STRESS-NEGATED LOTION?

The causes of stress are infinite. The cure? Still evasive.

You may continue with whatever methods you're using to manage stress — but now, there's a natural, drug-free alternative that can truly support your system: Stress-Negated Lotion.

• ✔️ Simply apply a small amount (5 ml) to a clean, hairless area of skin (such as chest or thighs)
• ✔️ Rub gently for less than a minute
• ✔️ Use once daily

Why Transdermal Polyphenols?

Polyphenols are abundant in foods like berries, grapes, apples, onions, and tea. However, when consumed orally, they lose much of their bioavailability due to breakdown by digestive enzymes.

With transdermal application, Stress-Negated Lotion avoids digestive degradation and delivers polyphenols directly into the bloodstream, preserving their therapeutic power.

HOW COMMON IS STRESS?

According to the American Institute of Stress:

• 33% of people report extreme stress
• 67% say stress negatively affects their physical health

And globally, it’s getting worse:

A 2024 Ipsos survey across 34 countries found that 60% of people felt stressed “to the point they could not cope” in the past year.

THE SCIENCE BEHIND THE FORMULA

The HPA Axis: Stress Response Center

The hypothalamic-pituitary-adrenal (HPA) axis plays a central role in the body’s stress response by regulating cortisol, the body’s primary stress hormone. Polyphenols may help modulate this axis, increasing resilience to stress-related dysfunction.

HOW BIOAVAILABLE POLYPHENOLS MAY HELP

1. Modulation of the HPA Axis

Supports better regulation of cortisol and the body’s stress response system.

2. Neurotransmitter Balance

Polyphenols may influence serotonin and dopamine levels — two key players in mood, motivation, and relaxation.

3. Fear and Memory Regulation

Certain polyphenols may affect how the brain processes and stores fear-based memories, reducing overreactions and anxiety.

4. Anti-inflammatory and Antioxidant Properties

Stress increases inflammation and oxidative stress, which damage brain cells. Polyphenols help:

• Reduce inflammation in the brain
• Protect neurons from oxidative damage

5. Mental Health Support

Some studies suggest that polyphenols may reduce symptoms of anxiety and depression, offering long-term psychological support.

March 2025 – National Institutes of Health:
“This flexibility is essential for acquiring new skills, consolidating memories, and recovering from brain injuries.”

NATURAL SUPPORT, NOT A DRUG

Polyphenols are not a pharmaceutical cure, but a natural and healthy response to what can be a debilitating condition. They are long-term therapy that begins working immediately.

• ✅ Safe for extended use — even lifelong
• ✅ Not a drug
• ✅ 100% plant-based micronutrients
• ✅ Best absorbed in bioavailable form through the skin

That’s exactly what Stress-Negated Lotion is designed for.